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Study of gel electrolytes properties by MR methods
Mrnka, Michal ; Gescheidtová, Eva (referee) ; Bartušek, Karel (advisor)
Theoretical part of the work deals with explanation of nuclear magnetic resonance phenomenon, relaxation processes in system of nuclear spins, basic techniques for measurement of relaxation times. There are described diffusion and techniques for diffusion coefficient measurement including method for suppressing the background gradient. Experimental part describes preparation of gel electrolytes samples and measurement of relaxation times. Sodium salt was used as a conductive agent. There is interpreted dependence of relaxation times on polymerization times and on concentration of conductive agent in gels.
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Dynamics of paramagnetic complexes observed by Nuclear Magnetic Resonance
Blahut, Jan ; Hermann, Petr (advisor) ; Botta, Mauro (referee) ; Dračínský, Martin (referee)
In this Thesis, structure and dynamics of paramagnetic complexes for medical application are studied by Nuclear Magnetic Resonance (NMR). It focuses mainly on development of contrast agents (CA) for Magnetic Resonance Imaging (MRI) which is one of the most effective radiodiagnostic method nowadays. Most of the MRI CAs contains paramagnetic complexes of d- and f-metal ions. The presence of unpaired electron in proximity of NMR active nuclei has two main effects: paramagnetically induced shift and paramagnetically induced relaxa- tion. Both processes can dramatically change the NMR spectrum and often make it unobservable at all. Nevertheless, in many cases, acquisition of such spectra is possible and sometimes even less time-consuming than observation of diamag- netic molecules. Enhanced T1 relaxation allows faster pulse sequence repetition and increased chemical shift dispersion may lead to resolution of originally over- lapped signals. Moreover, the analysis of paramagnetic effects can provide useful information about the structure and dynamics of the studied system. Theoretical background of these effects is described in the Introduction of the Thesis. In the first part of Discussion in the Thesis, a new class of contrast agents for 19F-MRI based on nickel(II) and cobalt(II/III) ions is introduced...
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Dynamics of paramagnetic complexes observed by Nuclear Magnetic Resonance
Blahut, Jan
In this Thesis, structure and dynamics of paramagnetic complexes for medical application are studied by Nuclear Magnetic Resonance (NMR). It focuses mainly on development of contrast agents (CA) for Magnetic Resonance Imaging (MRI) which is one of the most effective radiodiagnostic method nowadays. Most of the MRI CAs contains paramagnetic complexes of d- and f-metal ions. The presence of unpaired electron in proximity of NMR active nuclei has two main effects: paramagnetically induced shift and paramagnetically induced relaxa- tion. Both processes can dramatically change the NMR spectrum and often make it unobservable at all. Nevertheless, in many cases, acquisition of such spectra is possible and sometimes even less time-consuming than observation of diamag- netic molecules. Enhanced T1 relaxation allows faster pulse sequence repetition and increased chemical shift dispersion may lead to resolution of originally over- lapped signals. Moreover, the analysis of paramagnetic effects can provide useful information about the structure and dynamics of the studied system. Theoretical background of these effects is described in the Introduction of the Thesis. In the first part of Discussion in the Thesis, a new class of contrast agents for 19F-MRI based on nickel(II) and cobalt(II/III) ions is introduced...
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Dynamics of paramagnetic complexes observed by Nuclear Magnetic Resonance
Blahut, Jan
In this Thesis, structure and dynamics of paramagnetic complexes for medical application are studied by Nuclear Magnetic Resonance (NMR). It focuses mainly on development of contrast agents (CA) for Magnetic Resonance Imaging (MRI) which is one of the most effective radiodiagnostic method nowadays. Most of the MRI CAs contains paramagnetic complexes of d- and f-metal ions. The presence of unpaired electron in proximity of NMR active nuclei has two main effects: paramagnetically induced shift and paramagnetically induced relaxa- tion. Both processes can dramatically change the NMR spectrum and often make it unobservable at all. Nevertheless, in many cases, acquisition of such spectra is possible and sometimes even less time-consuming than observation of diamag- netic molecules. Enhanced T1 relaxation allows faster pulse sequence repetition and increased chemical shift dispersion may lead to resolution of originally over- lapped signals. Moreover, the analysis of paramagnetic effects can provide useful information about the structure and dynamics of the studied system. Theoretical background of these effects is described in the Introduction of the Thesis. In the first part of Discussion in the Thesis, a new class of contrast agents for 19F-MRI based on nickel(II) and cobalt(II/III) ions is introduced...
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Dynamics of paramagnetic complexes observed by Nuclear Magnetic Resonance
Blahut, Jan ; Hermann, Petr (advisor) ; Botta, Mauro (referee) ; Dračínský, Martin (referee)
In this Thesis, structure and dynamics of paramagnetic complexes for medical application are studied by Nuclear Magnetic Resonance (NMR). It focuses mainly on development of contrast agents (CA) for Magnetic Resonance Imaging (MRI) which is one of the most effective radiodiagnostic method nowadays. Most of the MRI CAs contains paramagnetic complexes of d- and f-metal ions. The presence of unpaired electron in proximity of NMR active nuclei has two main effects: paramagnetically induced shift and paramagnetically induced relaxa- tion. Both processes can dramatically change the NMR spectrum and often make it unobservable at all. Nevertheless, in many cases, acquisition of such spectra is possible and sometimes even less time-consuming than observation of diamag- netic molecules. Enhanced T1 relaxation allows faster pulse sequence repetition and increased chemical shift dispersion may lead to resolution of originally over- lapped signals. Moreover, the analysis of paramagnetic effects can provide useful information about the structure and dynamics of the studied system. Theoretical background of these effects is described in the Introduction of the Thesis. In the first part of Discussion in the Thesis, a new class of contrast agents for 19F-MRI based on nickel(II) and cobalt(II/III) ions is introduced...
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Study of gel electrolytes properties by MR methods
Mrnka, Michal ; Gescheidtová, Eva (referee) ; Bartušek, Karel (advisor)
Theoretical part of the work deals with explanation of nuclear magnetic resonance phenomenon, relaxation processes in system of nuclear spins, basic techniques for measurement of relaxation times. There are described diffusion and techniques for diffusion coefficient measurement including method for suppressing the background gradient. Experimental part describes preparation of gel electrolytes samples and measurement of relaxation times. Sodium salt was used as a conductive agent. There is interpreted dependence of relaxation times on polymerization times and on concentration of conductive agent in gels.
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